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[11] In this scenario, CAC offers rapid, direct identification after 48 h incubation, without Montelukast Sodium the need to subculture. The main drawback of this study was a limited number of samples. Therefore, conclusions may not be representative and may require further studies for confirmation. CONCLUSION HiCrome agar showed no major discrepancies in growth potential, colony characters and growth rates for primary isolation from sputum samples as compared to SDA. With few exceptions, the colony colors developed on HiCrome agar were stable and distinct for common Candida species. However, stable color development may take 48 h. We found results sugar fermentation tests were variable and had poor sensitivity, especially for detection of C. parapsilosis and C. glabrata. Based on these findings, we recommend routine use of HiCrome agar in mycology laboratories. Use of this differential media can significantly cut down the turnaround time as well as cost of sample processing. Footnotes Source of Support: Nil Conflict of Interest: None declared.""The intrinsic or mitochondrial pathway of apoptosis is initiated by DNA damage and endoplasmic reticulum stress, which leads to permeabilizations of the mitochondria outer membrane.[1] However, selleck inhibitor permeabilizations can either be permeability transition (PT) pore dependent or independent.[2] The PT pore is a calcium-sensitive mitochondrial channel, which allows the passage of molecules Akt signaling pathway of its zymogen (pro-caspase 9). Caspase 9 further activates downstream effector or execution caspases (caspase 3 and 7).[7] MMPT has therefore become a surrogate marker of cell death in pathologies such as AIDS, septic shock, and leukemias under chemotherapy.[2] The use of the medicinal plant in Africa for the treatment of diseases has risen over the years.[8] Olax subscorpioidea, which belong to the family of Olaceae is widely distributed in Nigeria and neighboring countries such as Zaire and Senegal.[9] It is recognized as ��Ifon�� in South-Western Nigeria and ��Aziza�� in the Eastern part of Nigeria.