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More patients with SRA were women, and had a history of frequent childhood wheezing, aspirin hypersensitivity and/or smoking (Table?2). Patients with severe asthma had on average six times more asthma exacerbations per year confirming a lack of full control of asthma despite a significantly higher dose of inhaled glucocorticosteroids (GCS) and more frequent use of oral steroids. Only 2.8% of patients with SRA did not report a single asthma exacerbation during preceding year while 58% of patients with non-SA did not have such exacerbation (P??35% Endonuclease (OR = 3.08; (1.739�C5.442; P?ABT-263 research buy almost 2-fold lower in patients with severe asthma. Although the mean FEV1% increased significantly after nebulization of 2.5?mg of salbutamol in both groups, on average, the increase was 2.3 times higher in patients with SRA when compared to non-SA. When individual responses to salbutamol were analysed, the postbronchodilator FEV1 increase was found to be significant (at least 12% from baseline) in 71.2% of patients with SRA and only in 25.7% of patients with non-SA. There was no difference between groups with respect to prevalence of positive prick tests (atopy), diagnosis of nasal polyposis or number of polypectomies. Patients with SRA had significantly higher total serum IgE and plasma ECP concentrations when compared to non-SA (Fig.?2A, B). Furthermore, ECP plasma levels were weakly associated with FEV1 and with blood eosinophilia (Table?3). EGFR inhibitors list Determination of specific IgE to SEs was performed in 194 patients with asthma and in 29 control patients. The sensitization rate to SEs was significantly higher among patients with asthma (76.1% and 71.1% in SRA and non-SA respectively) when compared to healthy controls (41.3%) as shown in Fig.?3. Although the sensitization rate was not significantly higher in SRA when compared to non-SA, the presence of specific IgE in serum tended to increase the risk for severe asthma [OR?=?1.94 (0.995�C3.788) P?=?0.052)]. With regression analysis, considering age as confounding factor, the presence of IgE to SEs was significantly associated with the following asthma severity markers: low respiratory function parameters (FEV1, FEV1/FVC, and MEF 25/75), increased bronchial response to albuterol (Table?3) and higher serum total IgE level (R2?=?0.29; P?