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2 A retrospective review was performed of the Indiana patients age HCS assay in addition to stomal and subfascial revisions. Kaplan-Meier survival and Cox proportional hazards analysis were used. Of those patients included (510), 214 patients underwent APV and 296 underwent the Monti procedure, half of which were spiral Monti. Median age at surgery was 7.4 years for those who had APV and 8.7 years for those who had a Monti procedure. Median follow-up was 5.7 years for those who had APV and 7.7 years for those who had the Monti procedure. Stomal stenosis and channel continence for APV versus Monti technique were similar (7.5% vs 7.4%; P = .99; and 98.1% vs 96.6%; P =.41, respectively). Fewer APVs (14; 6.5%) had subfascial revision compared with Monti procedures (49; 16.6%; P = .001). The probability at 10 years for a subfascial revision for the APV was 8.6%, Selleckchem GW3965 for Monti channels excluding spiral umbilical Monti technique was 15.5%, and for spiral umbilical Monti procedures was 32.3% (P Adenine .17). The authors show long-term outcomes using the APV and Monti techniques in a large cohort. The risk of channel complication is more than twice as high with Monti procedures as with APV, and continues over the channel��s lifetime. Dr. Saul Greenfield spearheaded the Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR) trial and presented an excellent review of the findings in his AAP Latimer Lecture entitled ��The Role of Antibiotic Prophylaxis with VUR �� Results of the RIVUR Trial.��3 The 2-year, multisite, randomized, placebo-controlled trial investigated the efficacy of trimethoprim-sulfamethoxazole prophylaxis in preventing recurrences (primary outcome) in 607 children with VUR diagnosed after a first or second febrile or symptomatic UTI. Secondary outcomes included renal scarring, treatment failure (a composite of recurrences and scarring), and antimicrobial resistance. The study shows that recurrent UTI developed in 39 of 302 children on prophylaxis as compared with 72 of 305 children who received placebo (relative risk, 0.55; 95% confidence interval [CI], 0.38�C0.78). Prophylaxis was shown to reduce the risk of recurrence by 50% (hazard ratio [HR], 0.50; 95% CI, 0.34�C0.74) and was most effective in children with a history of febrile UTI (HR, 0.