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These values are graphically represented in Figure?3. UNC2881 The images of gels were digitalized and analysed, as described earlier, and the optical density of the single SDS-PAGE bands was normalized to a percentage (Table?4). Comparing the lines of the gels in band number and per cent optical density, we can observe many differences between the groups. The CTR group had four characteristic bands numbered 7, 9, 22 and 24 (90, 71, 27 and 25?KDa, respectively); band number 22 was also found in CHM patients. NSG and SG groups both had five exclusive characteristic bands numbered 17, 18, 19, 20 and 21 (39, 36, 33, 30 and 28?KDa, respectively). Eight bands numbered 6, 23, 25, 27, 28, 29, 30 and 31 (94, 26, 24, 22, 21, 20, 19 and 18?KDa, respectively) were not detectable in the CTR group. Bands numbered 3 and 5 (127 and 100?KDa, respectively) were not detectable in CHM patients whereas band number 31 (18?KDa) was present only in this group. These interesting results are shown in Figure?4. RTB is a curable intraocular tumour, and collaborative efforts have been made to salvage the eye and vision. RTB treatment is complex and depends on many issues including tumour laterality, size, location, vitreous or subretinal seeding and macular involvement. Current treatments include cryotherapy, laser therapy, thermotherapy and plaque therapy, which are reserved for the management of selective RTB. Advanced disease may require enucleation (demolitive treatment) or chemoreduction, intraarterial chemotherapy and external radiotherapy (conservative treatment). The 18 patients who underwent enucleation in this study included five cases with secondary neurovascular glaucoma and five patients who failed the salvage attempt with direct intraarterial (ophthalmic artery) chemotherapy with melphalan; cases were all unilateral advanced RTB stage VB, eligible for enucleation. To our knowledge, proteomic analysis of the AH in RTB has not been reported before. AH was recently analysed in patients with other ocular pathologies such as myopia, acute corneal rejection and uveal melanoma, showing significantly higher total protein concentrations than in the AH from controls.31�C35 In this RTB series, protein concentration in the AH was also significantly higher than in controls (ANOVA: P?