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A convenience sample of 10 charts were abstracted in duplicate by the abstractors, and after standardization of the methods and protocols for the data management each abstractor continued independently on different data sets. Data abstractors met frequently to guarantee quality assurance, maintaining the same methods and protocols. Data Analysis Each control was matched 1:1 to each of the 474 RRT cases Fluvoxamine by age (+/? 5 years), sex, and ED diagnosis, defined by the final primary ED diagnosis in the record. No secondary diagnosis or comorbidity matching was performed. VS collected included heart rate, respiratory rate, blood pressure, and oxygen saturation. These were measured and manually entered to the medical record by registered nurses (RN) at the time of the patients�� visits. VS were categorized as the lowest 10%, middle 80%, and highest 10% based on the distribution of all 948 patients included. These cut-offs were selected based on clinical significance of the higher extremes. Comparisons of categorized VS (first and last heart rate [HR], systolic blood pressure [SBP], O2 Saturation, and respiratory rate [RR] in the ED) between the cases and controls were evaluated using conditional logistic regression models to account for the paired nature of the data. In terms of the timing of the VS records, we defined the first set was defined as the initial group in the record, while the last set was defined consequently as the last group of VS in the record. As described before, in our institution boarding of patients is non-existent; additionally, RNs are mandated to measure and record a set of I-BET-762 price VS prior to departure from the ED and notify the attending physician if VS are within RRT-activation criteria. Comparisons are reported as odds ratios (OR) with 95% confidence intervals (CI). We did not plan to perform sensitivity or secondary data analyses. Statistical analyses were performed using version 9.3 of the SAS software package (SAS Institute, Cary, NC). All tests were two-sided and p-values During the study period Pazopanib nmr (January 2009 to December 2012) there were 13,036 RRT activations at our institution. Of these, 1,259 were within 24 hours of admission from the ED (9.7%), and 522 within 12 hours of admission (4.0%). After removing patients with more than one RRT activation and patients who did not consent for medical record review (