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When comparing data from these children with data from 39 (51.3%) children with uncomplicated flu-like illness and negative PCR assay for pandemic influenza A/H1N1 2009 virus, no difference in disease duration, median age, red blood cell count, hemoglobin concentration, C reactive protein concentration, and absolute neutrophil Mdm2 count was observed, whereas significant differences were apparent when considering WBC count, relative and absolute lymphocyte count, absolute lymphocyte count z-score, and platelet count. Receiver operating characteristic curve analysis revealed that the best absolute lymphocyte count and absolute lymphocyte count z-score cut-points that simultaneously maximized sensitivity and specificity were 2,256 cells/?l and ?0.89, respectively, sensitivity being 0.81 (95% CI: 0.68�C0.94), specificity 0.87 (95% CI: 0.77�C0.98), positive predictive value 0.85 (95% CI: 0.74�C0.97), and negative predictive value 0.83 (95% CI: 0.71�C0.94). In conclusion, lymphocytopenia is selleck kinase inhibitor a marker for influenza A/H1N1 2009 virus infection in children. Absolute lymphocyte count selleck inhibitor time (PT) and activated partial thromboplastin time (APTT) as well as elevation of D-dimer levels. Biochemical abnormalities included elevated serum lactate dehydrogenase (LDH), aspartate aminotransferase (AST), creatine kinase (CK), alanine aminotransferase (ALT) activities, and increased C-reactive protein (CRP) concentration, as well as hyponatremia, hypokalemia, hypocalcemia, hypoproteinemia, and hypoalbuminemia. Arterial blood gas analysis revealed reduced arterial oxygen (PaO2) and carbon dioxide pressures (PaCO2).