CASK Not Necessarily A Miraculous fascination

Asthma severity, was on the other hand, clearly related to FeNO values, in line with the work of Delgado-Corcoran et?al. (27) but not with the study by Griese et?al. (28). Few previous studies have evaluated the relation between FeNO values and PS exposure in asthmatic children (2, 17, 19). Our results are consistent with those obtained by Warke et?al. (17), who found FeNO levels to be lower in exposed children as opposed to unexposed children. In contrast, the studies by Barreto et?al. (2) and Dinakar et?al. (19) failed to demonstrate a difference of FeNO levels in asthmatic children whether exposed or unexposed to PS, probably due to a lack of power (insufficient sample size) and to the heterogeneity of the studied population. For example, Barreto et?al. (2) included only 41 asthmatic children and only 25 of them were atopic. In the study by Dinakar CASK et?al. (19), only 13 PS? and 11 PS+ asthmatic children were investigated and more than one half of the children were taking anti-asthmatic treatments, able to reduce FeNO production. Moreover, in these studies, the statistical conducted analyses were mostly bivariate, and thus could not take into account potential confounders or FeNO risk factors such as age, allergen sensitizations, inhaled corticosteroid treatment and asthma severity. In our study, an effect of PS on FeNO values was demonstrated with a relatively smaller sample size compared to the study by Warke et?al. (17), which included 174 asthmatic children. Moreover, they did not take in account confounding factors. Franklin et?al. (20) published an opposite result, but they investigated a different population (infants younger than 2?years of age) and their sample click here was heterogeneous. In effect, only 36 of the 78 children included, had a history of wheezing. However, it is established that at the infant, the majority of wheezers are not authentic asthmatics but transient wheezers. Furthermore, the atopic status of these children was not investigated. This result, conflicting with those of all the other studies, whether in adults or in children, could be explained by the relative important proportion of allergic asthma in the group of infants exposed to PS. The results reported here are also in agreement with data concerning active smoking in selleckchem both healthy and asthmatic adults (6�C14). To the best of our knowledge, no epidemiological study, on the impact of PS, has been published in adults. Only two experimental works have demonstrated a real, but transient, reduction of FeNO values after brief and acute exposure to PS (6, 15). Our results also demonstrate the existence of a highly, significant negative correlation (r?=??0.41, P?