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5 mg/d oral eltrombopag. The dose was then adjusted every 1 or 2 weeks, based on the platelet counts, to maintain the target platelet count (�� 50,000 cells/?L). When patients achieved the target platelet count, we first reduced the dose of ITP medicines being administered concomitantly learn more with eltrombopag. We then reduced the eltrombopag dose to identify the lowest effective dose required to maintain platelet �� 50,000 cells/?L (maintenance dose). If the platelet count exceeded 2,500,000 cells/?L, eltrombopag administration was stopped. All patients were allowed to continue concomitant low-dose ITP medications at a stable dose, including rescue interventions. In patients who experienced relapse or were refractory to eltrombopag, romiplostim was started at 1 ?g/kg/wk, and the dose was then adjusted to achieve the target platelet count, increasing up to 10 ?g/kg/wk based on the patient's platelet count. Outcome measures and statistical analysis The response to initial therapy was evaluated after induction or salvage chemotherapy. Venetoclax datasheet A complete response (CR) was defined as a platelet count of 100,000 cells/?L, following the recommended criteria [14]. Conversely, a target platelet response was defined as an increase in the platelet count ��50,000 cells/?L, which was previously used in another large study of eltrombopag [2, 3, 17] and romiplostim [18, 19] to reduce the risk of bleeding. For between-group comparisons, Fisher exact test (categorical data) and the Mann-Whitney U test (continuous data) were used. Relapse-free survival (RFS) was analyzed using Kaplan-Meier survival curve estimates and the logrank test to compare differences in the distribution of survival in the 3 groups. A P value Histone demethylase median age was 55 years (range, 30-71 years), and approximately two-thirds of patients were women. The median platelet count at baseline was 14,000 cells/?L (range, 1,000-28,000 cells/?L). The median number of prior ITP treatments was 3 (range, 2-9), including 4 patients who had undergone a splenectomy. The median ITP duration before eltrombopag treatment was 28 months (range, 3.0-174.2 months). At baseline, all patients received concomitant ITP medications. Low-dose corticosteroids were the most common concomitant ITP medication (88.9%). Other therapies included cyclosporine, oxymetholone, and danazol. The median duration of eltrombopag treatment was 5.6 months (range, 1.2-42.3 months), and the median follow-up time was 40.5 months (range, 1.