The Engineering Behind Compound Library

The study was suspended at interim analysis for safety reasons with ITT being associated with increases in episodes of severe hypoglycaemia and adverse events. De La Rosa et al[42] also evaluated ITT in 504 ICU patients (61 with diabetes) and there was no mortality learn more or morbidity benefit observed, but an associated increased risk of hypoglycaemia, when administering ITT. In 2009, the NICE-SUGAR study compared ITT with conventional glucose control in 6029 ICU patients and established that the observations from the initial Leuven studies regarding ITT were not generalisable outside that specialised institution[41]. However, amongst the 1211 patients with pre-existing diabetes in the NICE-SUGAR study the administration of ITT did not appear more harmful than in patients without diabetes. The Glucontrol study[40], an international, Resiquimod multicentre trial involving over 1000 ICU patients was stopped early due to protocol violations, and it was, accordingly, underpowered. However, there was no evidence to suggest any benefit with ITT and data in patients with diabetes were not specifically described. Recently a number of studies have attempted to measure chronic glycaemia as a dynamic (HbA1c), rather than a binary, variable (i.e., presence of diabetes - yes/no) (Table ?(Table6).6). Egi et al[55] performed a retrospective observational study of 415 patients with diabetes (from two Australian ICUs) in whom glycated haemoglobin (HbA1c) had been measured within 3 mo of their critical illness and evaluated how this measure of pre-existing glycaemia impacted on the interaction between acute glycaemia and mortality[55]. It was reported that in patients with elevated preadmission HbA1c levels (> 7%) the number of deaths were significantly Compound Library screening fewer when blood glucose concentrations were > 10 mmol/L. Table 6 Observational studies that have recorded chronic glycaemia as a dynamic variable (chronological order) Consistent with this observation, we recently measured HbA1c on admission and glucose concentrations for the first 48 h of ICU admission[34] and observed that acute peak glucose concentrations were associated with increased mortality only in patients with adequate premorbid glycaemic control (defined as HbA1c