Uncommon Nevertheless Potential CASK Techniques

Twenty-five children (66%) reacted with positive and 13 children (34%) with negative DBPCFC (Table?2). Of the 25 reacting, ten claimed they had never eaten peanuts, and of the 13 nonreacting children, eight had the same claim while five reported a previous allergic reaction to peanut. The symptoms were scored according to Astier et?al. (6) and were mild to moderate (grade 1�C3) in fifteen (60%) of the reacting children. Nine children (36%) had severe reactions (grade 4), and one child (4%) was observed in the intensive care unit (grade CASK 5) (Table?2). No child reacted to placebo. No association was found between the threshold dose of peanut at challenge and the severity of the reaction (rs?=?0.21, P?=?0.32) (Table?2). Ninety-two per cent (22 of 24) of the children with a positive DBPCFC were positive in CD-sens after stimulation with peanut and 92% (23 of 25) after stimulation with Ara h 2 (Table?3) (Fig.?1). Two children were low responders, having a low response to the positive control, anti-Fc��RI, (find more to allow further evaluation. Seventy-seven per cent with a negative DBPCFC were negative in CD-sens after stimulation with peanut and Ara h 2. Three children negative in challenge had positive values in CD-sens to both peanut and Ara h 2, and all of them had also IgE-ab to these allergens. However, all children negative in CD-sens were negative in DBPCFC (Table?3) (Fig.?1) (A supplement consisting AZD6738 cell line of all CD-sens dose�Cresponse curves in Fig.?S1). Children with a positive DBPCFC had significantly higher levels of peanut CD-sens, 1.3 (range 0.4�C29.3) than negative children 0 (range 0�C0.5) (P?