What To Expect From BEZ235?

Following CA4P administration the maximum total BLI signal flux was significantly lower at all time points up to 48 hours. The lowest signal was observed at 4 hours (2.1 �� 106 vs. 8.5 �� 107 p/s baseline), representing a 97% average reduction, for the four tumors (mean baseline tumor volume = 569 �� 83 mm3). BLI signal remained low (less than 10% of baseline signal BLU9931 clinical trial intensity) until 48 hours after injection, but recovered to 45% of original signal by 72 hours. For OXi8007, the signal decreased from mean baseline of 2.2 �� 108 to 4.7 �� 106 p/s at 4 hours (98% decline, n = 6; mean baseline tumor volume = 705 �� 50 mm3), and remained significantly depressed compared with baseline after 72 hrs. Up to 48 hrs both the CA4P and OXi8007 signals were significantly decreased compared with saline, but did not differ between agents. At the 72 hour time point the integrated BLI (area under the curve) of OXi8007 remained significantly depressed compared with baseline (p 17-DMAG (Alvespimycin) HCl 4, 24, 48 and 72 hours post injection of saline ... Figure 3 Summary of BLI results for the treatment groups. (A) Relative BEZ235 concentration maximum light flux and (B) integrated area under the light emission curve following treatment: saline (control, n = 4), CA4P (120 mg/kg; n = 4) and OXi8007 (350 mg/kg; n = 6). Error bars represent ... Changes of tumor pO2 assessed by FREDOM Dynamic pO2 maps are shown for a representative tumor with respect to oxygen gas breathing challenge and administration of OXi8007 (Figure 4). Baseline pO2 was measured in about 50 voxels simultaneously (Figure 4A shows the 40 common voxels which could be followed over 200 minutes) revealing heterogeneity in pO2. The tumor was mostly well-oxygenated (mean pO2 = 47 �� 25 Torr) with small hypoxic fractions (HF5 and HF10 = 4%, and = 5%, respectively; Figure 4B). Hypoxia was essentially eliminated with O2-breathing and pO2 increased significantly to mean pO2= 228 �� 80 Torr (p