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The use of a combination of AaDO2 and pulmonary artery pressure has been used for classifying PE (19). The prognostic role of alveolar-arterial oxygen pressure differences with an acute PE has been demonstrated in the literature (13). The degree of pulmonary arterial obstruction was quantified according to the obstruction index of Qanadli et?al. This is a new CT index defined as the number of segmental arteries occluded and in relation to those arising distally to an occluded branch, with the integration of a weighting factor of 1 for partial and 2 for complete obstruction (20). The pulmonary artery obstruction index correlated significantly with all blood gas values. PaCO2 has a higher sensitivity, revealing the severity of PE (21). It has also been reported that there is ADAMTS12 a linear association between PE severity and PaO2 levels (22). Therefore the PaO2 level and the PaCO2 level are important parameters used to assess severity of PE and these parameters have been reported on the basis of radiological imaging. The risk determination with the help of PaO2/PaCO2 ratio in PE is very important because it reflects oxygenation and ventilation. Depth of hypocapnia is also critical issue. www.selleckchem.com/products/SB-431542.html In the present study, it was demonstrated that PaCO2?��?30 values provided the survival advantage. The present study also demonstrated the predictive power of PaO2/PaCO2. The ROC curves determined that the prognostic cutoff value of PaO2/PaCO2 ratio was 1.8, which may be an alternative method for adjusting the effect of a different fraction of inspired oxygen (FiO2) in clinical practice. To verify this result, future research will require an increased number of both hemodynamically learn more stable and instable PE patients who received different oxygen levels. In the present study, the NPV of PaO2/PaCO2?��?1.8 for hospital mortality were 93%. Figure?2 represents the relevant 90-day survival curves for mortality. These curves demonstrate a significant difference between 90-day mortality and survival, based on the cutoff value for PaO2/PaCO2 after adjusting for other significant interfering factors. In the literature, besides the RVD detected by echocardiography or CT, an elevated level of Tn-T is known to be associated with an increased risk of death and complications during acute PE (23�C25). In the present study, these prognostic parameters including increase RV/LV ratio on CT, abnormal level of Tn-T were found as predictors of mortality in agreement with previous studies (7, 24, 26�C28). It has been recommended that a second biomarker test both for Tn-T and N-terminal pro brain natriuretic peptid (NT-pro-BNP) should be analyzed 6�C12?h after an initially negative test in a PE patient with a symptom duration of