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AR-A004 showed significant and consistent cytotoxic activity against all the human cancer cell lines in this study, with IC50 values of 26?��g/mL, 19.5?��g/mL, 12?��g/mL, 28?��g/mL, 30?��g/mL, and 22?��g/mL for A549, HCT-116, PC3, A431, HeLa, and THP-1, respectively. Fig.?1 In?vitro cytotoxic activity of AR-A001 against various human cancer cells lines in the sulforhodamine B assay. Estimated IC50 values are 20?��g/ml, 22?��g/ml, 3?��g/ml, >100?��g/ml, ... Fig.?2 In?vitro cytotoxic activity of AR-A002 against various human cancer cells lines in the sulforhodamine B assay. Estimated IC50 values are >100?��g/ml, >100?��g/ml, >100?��g/ml, ... Fig.?3 In?vitro cytotoxic activity of AR-A003 against various human cancer cells lines in the sulforhodamine B assay. Estimated IC50 values are ARAF NA, NA, >100?��g/ml, >100?��g/ml, >100?��g/ml, ... Fig.?4 In?vitro cytotoxic activity of AR-A004 against various human cancer cells lines in the sulforhodamine B assay. Estimated IC50 values are 26?��g/ml, 19.5?��g/ml, 12?��g/ml, 28?��g/ml, ... 3.2. In?vivo anticancer activity of AR extracts against S-180 ascites in BALB/c mice Initial screening results for the effects of AR extracts on the learn more S-180 ascites model in mice are shown in Table?1. AR-A001 (100?mg/kg) and AR-A004 (80?mg/kg) elicited 73.56% and 72.16% inhibition in tumor growth with no mortality recorded. These effects were highly significant (p? to control mice, but significantly lower (p?Ceritinib solubility dmso with peak tumor cell growth inhibitory effects elicited at a dose of 120?mg/kg (79.51% and 89.98% inhibition, respectively). However, mortality was not recorded at this dose for AR-A001, while it was 60% in respect of AR-A004. Table?1 Effects of Aristolochia ringens (AR) extracts against sarcoma-180 (ascites) in BALB/c mice. Table?2 Effects of AR-A001 (80?mg/kg, 120?mg/kg) and AR-A004 extracts (100?mg/kg, 120?mg/kg) against sarcoma-180 (ascites) in BALB/c mice. 3.3. In?vivo anticancer activity of AR-A001 and AR-A004 extracts against S-180 solid tumor in BALB/c mice The effects of active extracts against S-180 solid tumor are shown in Table?3. AR-A001 (120?mg/kg) and AR-A004 (110?mg/kg) produced a significant reduction (p?