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Serum biochemical tests were performed and AFP and DCP levels were measured. Furthermore, ultrasound examinations were performed once every 1�C2 months, contrast-enhanced CT and/or MRI were performed once every 2�C6 months, and tests using other diagnostic imaging modalities were performed as required. The endpoints used in the present study were the date of death and the date selleck products of the final follow-up. The present study was completed in September, 2013 and the median follow-up period was 5.7 months (range, 0.2�C111.9 months). Statistical analysis Continuous variables are expressed as median values (range). Overall survival was determined by Kaplan-Meier analysis and differences between subgroups were compared with log-rank tests. A Cox proportional hazards stepwise model was used for univariate and multivariate analysis to identify any independent variables related to overall survival. Data from these models are expressed as hazard ratios (HR) and 95% confidence intervals (95% CI). All P-values were two-tailed and values Vandetanib chemical structure analysis are presented in Table II. As a result of the univariate analysis, we observed that Child-Pugh class (B+C), alanine aminotransferase (��80 U/l), WBC count (��6,000/l), NLR (��3), PLR (��111), AFP Itraconazole (��200 ng/ml) and tumor stage (T��3) were significant risk factors that were adversely associated with survival. The multivariate analysis revealed that hepatic functional reserve (Child-Pugh class B+C; HR=2.055; 95% CI: 1.592�C2.651, P