Representative records showing the difference in maximal transport rate of the Ca2 pump (PVmax) from the declining phase of the Ca2 -transient following the KCl- induced depolarization

A drastically larger [Ca2+]i could be calculated twenty and 40 seconds soon after the beginning of KCl application (112 nM, and 110 in handle, although a hundred and fifty nM and 135 in cloneC1 cells, respectively) indicating a reduced Ca2+-uptake ability of the SERCA pumps (Fig 4C). This was more quantified by extracting PVmax(maximal transportation rate of the pump see Supplies and To analyze the effects of oligomeric Ab (AbO) on hES mobile cholinergic neuronal differentiation we examined the gene expression profile adhering to publicity to AbO10 approaches), which was clearly lowered (p