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We evaluated VL:VM activation ratio and VM activation delay relative to VL activation in 39 PF pain subjects and 15 pain-free controls during walking. We classified the PF pain subjects into normal tracking and maltracking groups based on patellar tilt and bisect offset measured from weight-bearing magnetic resonance imaging. Patellar tilt correlated with Sitaxentan VL:VM activation ratio only in PF pain subjects classified as maltrackers. This suggests that a clinical intervention targeting vasti muscle activation imbalance may be effective only in PF pain subjects classified as maltrackers. ? 2011 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:927�C933, 2012 ""Previous research employing indirect measures of arch structure, such as those derived from footprints, have indicated that obesity results in a ��flatter�� foot type. In the absence of radiographic measures, however, definitive conclusions regarding the osseous alignment of the foot cannot be made. We determined the effect of body mass index (BMI) on radiographic and footprint-based measures of arch structure. Anti-cancer Compound Library in vitro The research was a cross-sectional study in which radiographic and footprint-based measures of foot structure were made in 30 subjects (10 males, 20 female) in addition to standard anthropometric measures of height, weight, and BMI. Multiple (univariate) regression analysis demonstrated that both BMI (��?=?0.39, t26?=?2.12, p?=?0.04) and radiographic arch alignment (��?=?0.51, t26?=?3.32, p?Alectinib order by Wiley Periodicals, Inc. J Orthop Res 30:1351�C1354, 2012 ""Articular loading is an important factor in the joint degenerative process for individuals with anterior cruciate ligament (ACL) rupture. Evaluation of loading for a population that exhibits neuromuscular compensation for injury requires an approach which can incorporate individual muscle activation strategies in its estimation of muscle forces. The purpose of this study was to evaluate knee joint contact forces for patients with ACL deficiency using an EMG-driven modeling approach to estimate muscle forces. Thirty athletes with acute, unilateral ACL rupture underwent gait analysis after resolving range of motion, effusion, pain, and obvious gait impairments.