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Regarding the timing of presentation to medical Ivacaftor mw facilities, a US retrospective study confirmed that diabetic patients are more likely to present in a delayed manner compared to non-diabetics (45% vs. 23% being admitted to hospital more than 24 hrs. post injury, p as indicated in a study of lower extremity burns (mean burn size of 4.2 �� 3.8% TBSA, range 0.5-15%) in diabetic patients treated at a US burn centre. The majority were found to be presenting to medical attention at a mean of 3.5 days after their injury (range 0-25 days). The mean difference between injury and obtaining medical care was 2.1 �� 3.6 days for patients with sensate vs. 9.5 �� 28.3 days for patients with insensate feet [12]. In addition, a considerable proportion of patients have poorly controlled blood glucose levels and comorbidities including cardiovascular disease, renal insufficiency and neuropathy [5,12,14]. Outcomes of diabetic burn patients: hospital inpatient treatment, length of stay and complications A ten-year retrospective review assessed outcomes of lower extremity burns in diabetic patients treated at the Fire-fighters Burn Institute, selleck chemical Davis Medical Centre. The mean hospital Oxymatrine stay was 5.65 �� 5.8 days per percentage TBSA. A total of 56 out of 68 patients (82%) underwent grafting, 19 needed readmission and 9 had at least one re-grafting procedure. The overall complication rate was 90% with a rate of 44% for local infection/cellulitis, 13% graft loss, 6% osteomyelitis and 4% gangrene. The cohort had a high amputation rate, with 11 patients undergoing procedures including below knee, transmetatarsal, and toe amputations. Two deaths were noted and seventeen others had serious complications including deep vein thrombosis, pulmonary embolus, respiratory and renal failure. Comparison between the insensate and sensate foot patients revealed that the rates of skin grafting (57% vs. 45%), amputation (24.3% vs. 6.5%) and length of stay (LOS) per TBSA (6.8 �� 6.5 vs. 4.3 �� 4.5 days) were statistically higher in the insensate foot subgroup [12]. Similar results were reproduced in a different retrospective US burn centre study with a higher proportion of diabetics needing surgery (72.6% diabetic vs. 32% non-diabetics, p