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The secondary outcomes Epigenetic inhibitors of the study included total duration of NIV, total length of stay until hospital discharge after randomization, and recurrence of AHcRF beyond 48?h after complete withdrawal of NIV. With no previous studies to guide effect size, the sample size was selected based on practical considerations. We estimated that there would be 100 patients admitted in our department presenting with AHcRF over 1 year, and among them half might have illnesses other than COPD resulting in respiratory failure, or would be receiving home NIV treatment prior to the index admission. We proposed to randomize 50 patients (25 patients per arm), which might allow the recruitment to be completed in 1 year. Results from this study would inform sample size calculation and study design for future RCT in the same area. With this sample size, we estimated that there would be a power of 0.81 for the study, provided the success rate of arm A was 0.31 and that of another arm 0.70 by PASS software (Power analysis and sample-size package, PASS, NCSS statistical software; NCSS, East Kaysville, UT, USA). Statistical analysis was performed with Statistical Package for Social Science Version 19 (IBM SPSS, Armonk, NY, USA). The primary outcome in both arms of the study was analysed by intention-to-treat and per-protocol analyses, while the secondary outcomes were analysed by an intention-to-treat analysis. Comparisons of continuous data between Alectinib solubility dmso the two groups were performed with unpaired Student's t-test or Mann�CWhitney Mianserin HCl U-test as appropriate; comparisons of categorical data were made with Fisher's exact test. Kaplan�CMeier plot and life-table analysis were used for analysis in time to discharge and failure from randomization. Comparison of timed data between the two groups was made with log-rank test. A P-value of