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Concerning these assessment values, various findings were reported.However, they are somewhat equivocal about the value and correlation of these tests to the degree of osseointegration, and there is no clear consensus as to when an implant achieves a minimum degree of stability to allow restoration into functional loading. To achieve good primary stability, more than 20�C30?Ncm of ITqV has been recommended. On the contrary, it has been postulated that high ITqV can lead to osseous necrosis due to ITqV higher than 40�C45?Ncm. Therefore higher ITqV has not been recommended. Although these concepts are widely accepted, Trisi denied compression necrosis of the bone through his goat experiment. Cefaloridine Implant outcome under high torque installation is a controversial issue. Aim/Hypothesis Monitoring the stability of the implant is key to implant treatment success. Assessment of high level ITqV bio-mechanical parameters in humans has not been commonly performed. Assessment and comparison of ITqV, ISQV, and PTV data were performed, using a new measurement device, which can detect insertion torque up to 100?Ncm. Material PLX-4720 in vivo and methods One hundred and sixty-seven dental implants of one-stage procedure (SwissPlus, Zimmer, USA) were tested. ITqV was assessed by the Torque-Lock (Intra-Lock) and Torque-Meter (Inplatex), RFA was detected by the OsstellTM Mentor (Integration Diagnostic AB), and PTV was measured by the Periotest (Gulden). Statistical analysis was made by the one-way ANOVA and Tukey's test. Results All fixtures were successfully treated. The averages of ITqV, ISQV, and PTV were, Osimertinib purchase 46.4?Ncm, 72.3ISQ, ?5.3PTV respectively. ITqV results were divided into three groups: low;