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Mental health includes: vitality (VI; feeling energetic), social functioning (SF; the extent to which physical health or emotional problems interfere with normal social activities), role emotional (RE; the extent to which emotional problems interfere with work or other daily activities), and mental health (MH; including anxiety, behavioral-emotional control, general positive affect). Subscales raw scores are standardized and vary from 0 to 100, where 0 implies the worst and 100 the best possible health status. Statistical analysis Scores at baseline were compared MRIP between the study sample and normative data using the one-sample t-test. The normative sample consisted of 608 healthy subjects drawn from the IQOLA Study.18 Repeated-measures ANOVAs with planned contrasts were performed on 5 consecutive measurements of SF-36 domains to test for within-group and between-group differences (depressed vs. non-depressed) over time. Planned contrasts were conducted to compare scores at each time point with the baseline. Type III sum of squares was used because of the unbalanced design. Statistical significance was established as P-values less than 0.05, and Greenhouse-Geisser correction was used when Mauchly��s test was significant. Results Demographic characteristics of sample The Temsirolimus research buy study sample included 49 patients with HCV (41% females), with a mean age of 49.5 years (SD=10.6, range=27-67). Six (12.5%) individuals developed depression during IFN-�� treatment (50% females; mean age 48.3��10.5 years). The normative group included 608 healthy individuals (46% females; mean age 34.8 years) drawn from the IQOLA Study.18 Comparison with healthy norms Compared with healthy norms, patients with HCV had significantly lower scores on PF (t=2.07, P=0.04), RP (t=3.69, Pwww.selleckchem.com/products/PD-173074.html (t=2.69, P