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0 to 3.9%. EGCG content decreased from February to April and then increased in June. The maximum content of EGCG reached to 9.6% in September. GHG content varied between 6.2 to 8.4%. Figure 2 Seasonal Changes of Catechins, GHG and Caffeine in PTE. Effects of PTE on High Fat Diet-induced Fat Accumulation in Mice The body weights of the control group exceeded those of normal group from day 7 to12 (Fig. ?(Fig.3).3). PTE (200 mg/kg) suppressed bodyweight gain from day 6 to 12 compared to control group. Final bodyweight in PTE group was significantly suppressed and the average body weight was same as normal group (Table ?(Table1).1). The weights of liver, epididymal fat and perirenal fat were also significantly suppressed by PTE. Regarding triglyceride content, serum TG and hepatic TG were also suppressed by PTE. Figure 3 Effect of PTE on HFD-induced Bodyweight Gain in Mice. Each point represents mean with the selleck chemicals llc S.E. (n=5-6). Asterisks denote significant differences PD0325901 supplier from control at * p in Mice Fed HFD. Each column represents mean with the S.E. (n=6). Asterisks denote significant differences from control at **: p on Lipid Absorption in Mice To confirm the effect of PTE on lipid absorption from the intestines, we examined the increase in serum TG after olive oil loading. PTE (100 and 200 mg/kg) significantly suppressed serum TG at 2 hr after loading of olive oil (Fig. ?(Fig.5).5). Orlistat (10 and 20 mg/kg) used as positive control also significantly suppressed TG elevation. Among the constituents in PTE, the polyphenolic compounds including GHG, EGCG and ECG did not suppress TG elevation. Although theobromine Oxymatrine did not suppress TG elevation, caffeine (25 and 50 mg/kg) significantly suppressed the elevation at the point 2 hrs after olive oil ingestion. Figure 5 Effect of PTE and Its Constituents on Serum TG Elevation in Olive Oil-loaded Mice. Each point represents mean with the S.E. (n=6). Asterisks denote significant differences from control at * p