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Supporting Information Supporting Information is available at Journal of Cachexia, Sarcopenia and Muscle online. Figure?S1. Ghrelin prevents the decrease in myofiber size caused by tumour or cisplatin. (A) Immunofluorescence staining for anti-laminin antibody of TA muscles in LLC-induced cachexia. Venetoclax Laminin staining (green) outlines myofibers. Dapi was used to stain the nuclei (blue). (B) Immunofluorescence staining for anti-laminin antibody of TA muscle in cisplatin-induced cachexia. (C) Average cross-sectional area of myofibers in LLC-induced cachexia. (D) Average cross-sectional area of myofibers in cisplatin-induced cachexia. HK-V represents the group injected with heat-killed (HK) LLC and vehicle. T-V and T-G group represent animals inoculated with LLC (106 cells) receiving vehicle (saline) or ghrelin (0.8?mg/kg twice daily), respectively. V, vehicle-treated group, C, cisplatin-treated group; CG, cisplatin?+?ghrelin-treated group; G, ghrelin-treated group. *P?Histone demethylase ���P?Enzalutamide info item Click here to view.(402K, tif) Supporting info item Click here to view.(14K, docx)""Cachexia is a severe medical complication of cancer and considered to be a significant cause of morbidity and mortality affecting up to two-thirds of cancer patients.1 People affected typically experience loss of weight, which is often accompanied by anorexia and other associated symptoms and usually occur n conjunction with the development of cachexia.2,3 However, cancer cachexia remains under-recognized and untreated in clinical settings because definitions, diagnostic criteria, and classification schemes have not yet been established.4�C6 Studies have shown that cancer cachexia has a complex pathophysiological mechanism and is not solely due to nutritional deficiencies. Cachexia appears to be associated with disease-mediated metabolic disorders, inflammatory responses, and insulin resistance.7,8 In spite of the emerging knowledge of the aetiology of cachexia, the emphasis of clinical treatment and management is traditionally focused on patients with weight loss greater than 5% over the past 6?months. It is these patients that are often judged by clinicians as being in a cachectic status.9 Currently, treatment for cancer cachexia predominantly focuses on nutritional and pharmacological interventions for improving patients' calorie intake, albeit the evidence supporting their effectiveness in relation to body weight and quality of life is inconclusive.