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, 2011a, Brookes et al., 2011b, de Pasquale et al., 2010?and?Liu et al., 2010). The interaction signals were added to the basic broadband source timecourses and multiplied by a dipolar lead field to generate simulated MEG data. Empty room noise data were then added to the simulated source data. These data were processed using the technique outlined in the theory section, with the seed location taken to be the simulated source in the right motor region. ��2 images depicting simulated connectivity were reconstructed on a 5?mm cubic grid spanning the entire brain. This process was repeated with and without signal leakage correction (in the case without signal leakage correction yR?=?y). In order to test the multivariate statistical approach, along with our approach to eliminating linear interactions, we ran four sets of simulations www.selleckchem.com/products/Romidepsin-FK228.html each containing multiple noise realisations. In all cases sources were simulated as http://www.selleckchem.com/products/U0126.html above but with no simulated interactions. Source timecourses comprised Gaussian random noise frequency filtered into the 1�C150?Hz band with amplitude 5?nAm. The source orientations were tangential to the radial orientation but randomised with respect to the azimuthal direction. 1) A single source was simulated in the right primary motor area. The source timecourse was constructed as above, and empty room noise data were added. ��2 images were constructed taking the seed location to be that of the simulated source and using voxels spaced 1?cm apart on a regular cubic grid spanning the entire brain. 500 realisations of this simulation LMTK2 were run, with both the simulated source timecourse, and the empty room noise, changing for each realisation. Signal leakage correction was applied in all cases. In all simulations, a single false positive was defined as a realisation of the simulation in which one or more voxels was significant at (p?