Overview - The RGFP966 Benefits As well as Cons

76, p=0.0012 for IMI; F(1,33)=17.84, p=0.0002 for FLX], but no or weak effect of 6h��3d RST treatment [F(1,31)=1.926, p=0.1751 for IMI; F(1,33)=4.134, p=0.0501 for FLX], and no antidepressant��RST interaction [F(1,31)=1.730, p=0.1981 for IMI��RST; F(1,33)=0.6891, p=0.4124 for FLX��RST] (Fig. 2F). In the subsequent assessment of food consumption, Pifithrin-�� cell line mice treated with chronic IMI showed slightly reduced food consumption, whereas mice treated with chronic IMI followed by 6h��3d RST treatment did not. Mice treated with chronic FLX exhibited reduced food consumption, and mice treated with chronic FLX followed by 6h��3d RST treatment also showed reduced food consumption, although the amount of food consumed was slightly enhanced after 6h��3d RST treatment (Fig. 2G). Two-way ANOVA analysis detected the main effect of chronic FLX treatment [F(1,33)=17.03, p=0.0002], but not IMI treatment [F(1,32)=4.014, p=0.0537]. There was no effect of 6h��3d RST PDK4 treatment [F(1,32)=1.175, p=0.2865 for IMI; F(1,33)=0.5669, p=0.4568 for FLX], and no interaction between chronic IMI or FLX treatment and 6h��3d RST treatment [F(1,32)=1.037, p=0.3162 for IMI��RST; F(1,33)=0.4668, p=0.4992 for FLX��RST] (Fig. 2G). Chronic IMI or FLX treatment in normal mice tended to suppress the number of marbles buried in the marble burying test (MBT). The 6h��3d RST treatment in normal mice decreased the number of marbles buried. Chronic FLX treatment followed by 6h��3d RST treatment suppressed the number of marbles buried to the level that was lower than that by chronic FLX treatment (Fig. 2H). Two-way ANOVA analysis detected the main effects of chronic IMI or FLX treatment [F(1,32)=6.273, p=0.0175 for IMI; F(1,33)=33.17, pEpigenetics inhibitor Chronic IMI treatment in normal mice significantly decreased immobility time in the tail suspension test (TST) (Fig. 2I). The 6h��3d RST treatment in normal mice did not significantly change immobility time in the TST. Chronic IMI treatment followed by 6h��3d RST treatment also decreased immobility time in the TST compared with chronic IMI treatment (Fig. 2I). Chronic FLX treatment in normal mice significantly reduced immobility time in the TST. Chronic FLX treatment followed by 6h��3d RST treatment suppressed immobility time in the TST compared with chronic FLX treatment (Fig.