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Both find more in vitro and in vivo testing did not find a response to supplemental hydroxocobalamin. After discontinuation of hydroxocobalamin in one patient, serum MMA level remained elevated but stable, while urine MMA increased. Both patients have remained asymptomatic with normal development. The observed homozygous p.P86L mutation in the N-terminal extended segment may yield reduced MCM activity and is refractory to hydroxocobalamin supplementation, while not inducing a metabolically unstable phenotype. These genotype�Cphenotype associations further enhance the understanding of methylmalonic acidemia, which will continue to improve patient care. ""63736" "Background:? We determined the prevalence and risk factors for late-onset bloodstream infections (LO-BSI), the distribution of pathogens and the outcomes of affected preterm infants. Methods:? The records of all preterm infants (learn more in the neonatal intensive care unit for >3 days were retrieved for this retrospective matched case�Ccontrol study. Results:? A total of 108 out of 1459 preterm infants (7.4%) had 142 episodes of LO-BSI. The highest LO-BSI rate (44%) was among 198 very-low-birthweight infants (Oxacillin indicator of early vascular changes signaling the development of vascular disease. The objective of the current study was to screen aortic elastic properties with tissue Doppler imaging in obese children. Methods:? We examined 37 obese children and 30 age- and sex-matched normal subjects. Anthropometric measurements and metabolic risk profile were assessed in a physical examination and with blood taking. The subjects were divided into two subgroups: those with and without metabolic syndrome. Internal aortic systolic and diastolic diameters by M-mode echocardiography and aortic systolic upper-wall tissue velocity by tissue Doppler imaging were measured 3?cm above the aortic valve. Aortic distensibility and aortic stiffness index were calculated using accepted formulae.