So How Does Dactolisib Work?

34 68 Also, no previous RCT has examined the trio of outcome categories (1) metabolic control (by HbA1c); (2) MK0683 solubility dmso patient reported quality of life (EQ-5D); and (3) cost-utility (using QALYs calculated from the EQ-5D). It will also be one of the first studies to evaluate the efficacy of GMVs in promoting PA as measured objectively (SenseWear accelerometer).69 70 This study is an efficacy trial that if successful is intended to inform a potential province-wide (BC) implementation of this particular GMV healthcare service delivery model. Given this larger intention, it makes sense to have ��Usual Care�� (individual visits) as our comparator given that Usual Care is the current standard of practice. Our choice of single-blinding (measurement team) is the most reasonable in the light of the impossibility of the care providers leading the GMV to not know who was in their particular arm of the study. With 34 of 128 participants recruited, we have only a single physician within a single clinic involved in the study. At this point, there is no unequal expertise of care providers or centres in each group. We address the limitations below. Limitations/generalisability Currently, our RCT is limited to one geographic location and one clinical setting with a relatively homogeneous population; findings may not be generalisable to other regions, settings and/or demographic populations. Given that a single physician along with other specific healthcare professionals is leading the intervention, the findings may not be generalisable to other practitioners. Conclusion Our study will apply conceptual clinical innovations in GMV in the primary care setting to the health need of older adults with diabetes. There is a need for quantitative Canadian research in GMV broadly and we target the substantial clinical problem��diabetes in older people. Do primary care-led GMV reduce HbA1c and improve quality of life��and do they do so at a reasonable price? If the answer is encouraging, there is potential to ��scale up�� the model via divisions, provinces and, ultimately, nationwide. Footnotes Contributors: KMK provided overall supervision for the protocol, advising on design, implementation, statistical analysis and the final manuscript and was the lead author of the manuscript. AW advised on study design and recruitment and led the Group Medical Visits. JCD oversaw the planned statistical analysis and advised on the final manuscript. MD, TL-A, KM, CAM, LH, CH and DJA advised on the design and implementation of the study, and on the final manuscript. All authors have approved the final article. Funding: This study is funded through the UBC Endowment Fund (private donor). The BC Ministry of Health provided funding for Exercise is Medicine BC, through which this study was also partially funded.