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The results are described below. Table 3 Results of mediation analyses testing novelty seeking as a mechanism in the pathway of risk for substance initiation and use. Novelty seeking subdimensions as mediators of the association of family history with lifetime initiation and past 30-day frequency of substance use Family history score (IV) was associated with higher levels of impulsiveness (M; a1 path; �� = 0.04, SE = 0.01, P learn more impulsiveness (M) was significant (ab1 path: �� = 0.04 [95% GUCY1B3 bias-corrected CI = 0.01�C0.09], SE = 0.02, Z = 2.43, P �� = 0.01, SE = 0.01, P = 0.30). Additionally, the indirect effect of family history (IV) on substance initiation (DV) through exploratory excitability (M) was not significant (ab2 path; �� = 0.01 [95% bias corrected CI = ?0.01�C0.05], Gefitinib order SE = 0.01, Z = 0.86, P = 0.39). The pattern of results was the same in models testing past 30-day frequency of use as the IV. The results of these models are displayed in Figure 1. Figure 1 Mediation models testing TCI novelty seeking dimensions, impulsiveness, and exploratory excitability in the relationships among family history of substance use and early adolescent substance use (n = 556). Mediation was tested via the products of the ... Subjective effects as a mediator of the relationship of novelty seeking subscales and frequency of substance use In these models of the subsample of individuals who reported using at least one of the six substances in the past six months and reported on subjective effects of those substances over that time frame (n = 230), impulsiveness (IV) was associated with higher levels of positive (M; a1 path; �� = 2.11, SE = 0.99, P