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By adopting a suitable surgical protocol in this circumstance, one can improve the survival rates of implants placed in a biologically challenging environment, thereby providing patients with a more cost- and time-effective management. ""M. Alkhraisat1, E. Anitua2, A. Murias-Freijo2, G. Orive1 1Eduardo Anitua Foundation, Vitoria, Spain2Clinica Eduardo Anitua, Vitoria, Spain Background The restoration of missed single molars requires careful planning to accomplish prosthetic rehabilitation with satisfactory function and adequate oral hygiene maintenance. Limited mesio-distal (Adenylyl cyclase the insertion of two implants for single molar restoration. In case of single implant placement, dimensional discrepancies between the implant and restoration will result in unfavourable contours leading to poor esthetics and hygiene. Aim/Hypothesis Assess the long-term success of offset implant placement for prosthetic rehabilitation of missing single molars with limited mesio-distal space. Report the results of Prosthetic complications, implant survival and marginal bone loss after 5�C10?years of follow-up. Material and methods Patients with implant-supported single molar restorations were revisited to select cases with offset BIBF1120 implant placement and follow-up time of at least 5?years. Radiographical and clinical examinations were realized to retrieve data about patients dental and medical history, The occurrence of prosthetic complications, mesio-distal dimension of the edentulous space, crestal bone loss, and implant loss were also analyzed. Results Forty-eight patients (28 were females) participated with 53 single implant supported restorations. Mean age was 51?��?12?years, four patients were smokers and four have a previous history of periodontal disease. The follow-up period was up to 10?years and three Selleck GS-7340 implants loss were occurred. The antagonist type was natural dentition in 78% of the restorations. All implants placement was shifted distally with the exception of one implant that was placed mesially. Prosthetic complications were absent at the time of data analysis. The proximal bone loss around the dental implant was