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28 The objectives of the current study were to evaluate the association of BMI with HRQoL, health utilities, health care resource utilization, productivity loss, activity impairment, and direct and indirect SB431542 ic50 costs. This information, based on large-scale survey methodology, will provide critical insight into the potential broad and significant impact of obesity among the European population. Methods Sample The current study includes data from the 2013 EU5 (France, Germany, Italy, Spain, UK) National Health and Wellness Survey (NHWS; N=62,000), a nationally representative, online survey of respondents aged ��18 years. A random sample, stratified by sex and age, was taken to ensure that the demographic composition of the sample was identical to that of the corresponding adult population in each country as measured from the international database of the United States Census Bureau. The survey sample was drawn from the general population using the Internet panel maintained by Lightspeed Research (Warren, NJ, USA), which includes members of the USA and EU5 countries who agreed to participate in survey research. Panel members complete in-depth demographic registration profiles that are used to randomly sample panel members for a survey in order to ensure a representative sample. To ensure a representative sample, particularly in the 65+-year-old population, online recruitment was Megestrol Acetate supplemented by computer-assisted web interviews, Ruxolitinib in vivo where respondents were recruited on the telephone and had the choice to complete the interview on the phone or were emailed a link to the survey to complete on their own (France =430, Germany =840, Italy =864, Spain =667 [computer-assisted web interview was not performed in the UK]). Institutional review board (IRB) approval was granted by the Essex IRB (Lebanon, NJ, USA). All respondents took part voluntarily and provided informed consent. This analysis profiles adult respondents by BMI category. The NHWS asked respondents their height and weight information, from which BMI was calculated. Respondents who did not provide weight information or were categorized as underweight were excluded from this study. The following weight categories were used: normal weight (BMI ��18.5 kg/m2 to BMI