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Further adjustments for overall obesity (assessed by BMI) and central obesity (assessed by WC and WHR) indicators were included to assess the independent and joint effects of the upper trunk anthropometric index in predicting type 2 diabetes. The characteristics of participants by gender are presented in Table 1. Compared to the women, the men were heavier and taller and had a lower BMI, body fat mass, and fat percent. Additionally, men OSI-906 molecular weight had larger anthropometric indices and higher risk of type 2 diabetes than women. BMI and all anthropometric indices were associated with type 2 diabetes. The ROC analysis indicated that THC had a stronger relationship with type 2 diabetes than BMI, NC, or WC (men: AUC?=?0.551 versus 0.533, 0.535, and 0.541; women: AUC?=?0.578 versus 0.559, 0.545, and 0.559). THR and WHR (men: AUC?=?0.577 and 0.564; women: selleck chemicals AUC?=?0.606 and 0.582) were stronger markers of type 2 diabetes than BMI and other anthropometric indices. The optimal cutoff points estimated by the Youden index for predicting diabetes for THR and WHR were 0.93 and 0.93 in men and 0.88 and 0.90 in women (Table 2). Each increase in the SD of the THR was associated with a 1.29-fold (1.15�C1.45) and a 1.48-fold (1.29�C1.70) increase in the odds ratios of type 2 diabetes in men and women, respectively (p?flupentixol and study center, THR and WHR still had a stronger association with type 2 diabetes than BMI and other anthropometric indices. The adjusted ORs for the second, third, and fourth quartiles of THR were 1.48 (1.02�C2.14), 1.91 (1.33�C2.75), and 2.11 (1.47�C3.04) in men and were 1.65 (1.05�C2.59), 1.61 (1.02�C2.56), and 3.40 (2.18�C5.31) in women, respectively, whereas those values for WHR were 1.53 (1.07�C2.20), 1.47 (1.02�C2.12), and 1.95 (1.37�C2.77) in men and 1.60 (1.03�C2.49), 1.67 (1.07�C2.61), and 2.31 (1.48�C3.60) in women, respectively ( Table 3). The second objective of this study was to determine whether THR, the upper-trunk-related anthropometric index that was most related to type 2 diabetes, was an independent determinant of type 2 diabetes to overall and central obesity indicators. Because the data showed that WHR was more closely associated with type 2 diabetes than WC, a comparison of the magnitude of the association with type 2 diabetes was conducted between BMI, WHR, and THR. The multiple logistic regression analysis showed that the adjustment for potential confounders and BMI slightly attenuated the association between THR and WHR with type 2 diabetes (Supplementary, Table S1).