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The main findings are further discussed in more detail below. Ten studies offered varying estimates of incidence rates as shown in Table S1 [24, Otenabant 31, 44, 50-52, 56-59]. These ranged from 1.5 per 100?000 person-years [24] to 32 per 100?000 person-years [45]. In one study, over a 4-year period, anaphylaxis was the cause of 0.1% of children's hospital admissions and 0.3% of adult admissions [50]. Pooled analysis was not possible due to the heterogeneity of the populations and the different approaches to reporting incidence in these studies. The descriptions used in studies typically failed to differentiate clearly between measures of point, period, and lifetime prevalence. Quantitative data were available for pooling from three population-based studies [26, 39, 57]; in which estimates of prevalence ranged from 1 of 1333 (0.1%) [57] to 37 of 6676 (0.6%) [39]. Meta-analysis (I2?=?99.9%) yielded a pooled prevalence estimate of 0.3% (95% CI 0.1�C0.5), as shown in Figure?3. In a study of 325?046 people, a peak incidence of 313.58 per 100?000 person-years MI-773 nmr was noted in the 0- to 4-year-old group; this was significantly different (P?Ribociclib supplier of anaphylaxis have been reported [44, 51, 57]. The incidence of hospital admissions for anaphylaxis increased from 5.6 per 100?000 discharges in 1991�C92 to 10.2 per 100?000 discharges in 1994�C95 [44]. Age�Csex standardized incidence was estimated as 6.7 per 100?000 person-years in 2001, rising to 7.9 per 100?000 person-years in 2005 [57]. Anaphylaxis rates rose from 6 to 41 per million admissions between 1990�C91 and 2000�C01 [51]. On a similar note, the lifetime age�Csex standardized prevalence of recorded diagnosis of anaphylaxis was 50 per 100?000 in 2001, rising to 75.5 per 100?000 in 2005 [57]. The key triggers identified in these studies included foods, medications, stinging insects, and latex. Comorbidities such as atopic eczema/dermatitis and asthma were also found to be important [30].