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Foci of brown fat may be found in the mediastinum, retroperitoneum and axillae of some normal adults. Unlike other adipogenic tumors, hibernoma contains abundant mitochondria and is highly metabolically active and therefore, unlike conventional lipoma, ��hot�� or AZD3759 in vivo ��glucose-avid�� on FDG CT�CPET. Metastases, however, have never been documented. On ultrasound (US), hibernoma is typically described as a well-defined echoic mass. On magnetic resonance imaging (MRI), the lesion usually demonstrates signal intensity intermediate between that of skeletal muscle and subcutaneous fat on both T1-weighted and T2-weighted images, and exhibits contrast enhancement owing to its hypervascularization. At CT correlation, brown fat uptake corresponds to a density of ?50 to ?150 Hounsfield Units (HU). The physiologic similarities between brown fat and malignancy often lead to brown fat mimicking malignancy on FDG CT�CPET. This can SIS3 nmr easily cause diagnostic uncertainty, particularly when brown fat presents in a similar pattern as nodal uptake as in our case. Moreover, hibernomas demonstrate uptake values similar to those described for liposarcomas, and thus biopsy is required to exclude a malignant etiology. Accurate assessment is crucial because misinterpretation could lead to inappropriate therapeutic approaches like unnecessary invasive staging and diagnostic procedures or follow-up imaging with additional radiation exposure. Although hibernoma would not normally be subject to CT�CPET scanning, in the setting of a known malignancy and routine oncologic follow-up, it can lead to a false-positive diagnosis of metastasis. This diagnosis should therefore be taken into consideration in FDG avid masses of the soft tissues during oncologic follow-up. ATP12A Anne Collins edited the English text. The authors declare no conflict of interests. ""Our objective was to retrospectively review the incidence and outcome of asymptomatic patients recalled from screening due to bilateral axillary adenopathy (BAxA) with an otherwise normal mammogram. This study included all women recalled from screening due to BAxA that underwent ultrasound guided biopsy between July 2004 and April 2010. Women with a known etiology for adenopathy were excluded. One radiologist blinded to biopsy outcome evaluated mammographic lymph node characteristics. Twelve of 74,926 screening mammograms (0.016%) performed during the study period met inclusion criteria. Five women (41.7%) had non-Hodgkin lymphoma (NHL); two had long axis dimension of