A New Perspective On KU-55933 Now Circulated

Performed in the pulmonary CYTH4 clinic and inpatient of internal medicine of RSMH Palembang, from March 2012 to January 2013. Samples that meet the inclusion and exclusion criteria drawn up by consecutive sampling until number of 30 cases and 60 controls. Results?A total of 90 subjects, comprising of 57% men and 43% women with a mean age of 37 years. TNF-��cut-off point levels is 2.927?pg/ml, odds ratio 2.983 and 95% confidence interval 1.202�C7.408. The mean TNF-�� serum level in pulmonary TB is 6.99?��?10.45?pg/ml, were significant higher than no TB 3.59?��?3.11?pg/ml. Conclusion?There is significant difference TNF-��serum level in pulmonary TB and no TB. There is a significant association between TNF-�� serum level with pulmonary tuberculosis incidence. Keywords?Pulmonary tuberculosis, TNF-��. ZEN AHMAD, SUDARTO J LIASIM, DIESRIQA INDRA Department of Internal Medicine, University of Sriwijaya, Palembang, Indonesia Background?T cell helper-1 (Th-1) plays an important role in immune system, especially for intracellular bacterial infections. One of the cytokines produced by Th-1 cells is interferon-gamma (IFN-��), which plays an important role in eliminating the M.tuberculosis. This study aimed to see if there KU55933 was a level of IFN-��with pulmonary TB incidence. Method?Serum levels of IFN-��were measured by ELISA in 30 TB patients, 32 patients with tuberculin test >10?mm and 28 patients with tuberculin test?10?mm 8.36?��?1.76?pg/mL with a range of 5.56 to 12, 80?pg/mL, and in 28 subjects with tuberculin test?MK-1775 cell line were no significant differences among the three groups and no correlation with the incidence of pulmonary tuberculosis. Serum levels of IFN-��can be used as a marker of TB infection but can not determine active or latent TB. Key Words?Pulmonary tuberculosis, tuberculin skin test, IFN-��. SUZANNA JAPPAR, SU YING LOW Singapore General Hospital, Singapore Background?Poor compliance to tuberculosis (TB) treatment has many adverse consequences including longer treatment period, drug resistance, relapse and the possibility of infecting others. Aim?To profile tuberculosis patients who missed their appointments.