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At the third wave of the study in 1991�C1993, the participants were asked to report whether they suffered from asthma based on the question: ��Do you suffer from asthma?�� They were also asked to answer the following question on allergic reactions: ��Do foods, medicine, grass, flowers, animals, or other things make you suffer from asthma, hay fever, or eczema?�� This question was used to define allergic asthma, allergic rhinitis, or atopic dermatitis. Finally, they were asked whether they currently had a daily intake of asthma/bronchitis medication. Information on asthma hospital admission was obtained from the Danish Hospital Registry, which has consistently used codes from the International Classification of Diseases (ICD), version 8 and, from 1994, version 10. Hospital admissions selleck kinase inhibitor were defined as asthma related if the following codes were assigned at discharge: ICD-8 code 493; ICD-10 code J45. The hospital registry is updated until August 8, 2010. The vital status of the study population was followed in the Central Death Registry. The participants were followed until date of first asthma hospital Quinapyramine admission, death, emigration, or end of follow-up. Less than 0.1% were lost to follow-up owing to emigration. Other covariates included sex, age (continuous), education (80% of predicted FEV1). Lung function was assessed from objective measurements of FEV1 by spirometry in accordance with standards from the American Thoracic Society and the European Respiratory Society [9]. Lung function was expressed as percentage of the predicted value based on age, gender, and height. The regression of predicted FEV1 is based on lifelong nonsmokers in selleck chemical the Copenhagen City Heart Study (women: FEV1 (ml)?=??1431 ? 28.5?*?age (years)?+ 34.5 * height (cm); men: FEV1 (ml) =??3763 ? 35.2?*?age (years)?+ 52.9?*?height (cm)). The analyses were also adjusted for tobacco smoking (never-smoker; ex-smoker; smoker of 1�C14?g/day, 15�C24?g/day, and more than 24?g/day), alcohol intake (