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After surgery, all patients received a continuous infusion of dopamine at a rate of 10?��g?1��kg?1��min?1 and were transferred to the ICU. The infusion rate of dopamine was gradually decreased when artery systolic pressure ��80?mmHg and central venous pressure ��12?cm H2O and stopped when the infusion rate was 3�C5?��g?1��kg?1��min?1, and hemodynamics were stable. Data were expressed as mean?��?sd and were analyzed by spss software (SPSS Inc., Chicago, IL, USA). All categorical variables were tested by chi-squared test. All normally distributed data (tested by Kolmogorov�CSmirnov test) were analyzed using two-tailed Student's t-test. Repeated measures (conformed to compound symmetry, tested by Mauchly's test) were analyzed using one- and two-way analysis of variance (anova). A difference with a P?Selleck CHIR 99021 significant. A total of 32 children scheduled to undergo surgical repair of ventricular septal defect under CPB Fleroxacin were considered for participation in the study. However, parents of one child refused, another child had the history of asthma and did not fulfill the exclusion criteria. Therefore, 30 children were randomized and 15 children in each group. There was one child in each group whose VSD was closed through an incision in the main pulmonary artery different from other children and not included in the statistical analysis (Figure?1). The general characteristics of the study patients were shown in Table?1. Number of cases, age, gender, weight, and base cardiac function did not differ between the two groups. Hemodynamic Parameters were shown in Table?2. Values of HR at T1, T2, T3, and T4 in the esmolol group were significantly lower than those in the control Y-27632 mouse group (P??0.05). Clinical observation indexes were shown in Table?3. CPB time, cross-clamp time and the rate of heart spontaneous rebeating were not statistically different between two groups(P?>?0.05). Compared with the control group, cumulative postoperative dosage of dopamine in the esmolol group significantly decreased (P?
