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References in all relevant articles as well as the reviewers�� personal collections of articles on allergic conjunctivits were also searched. In this systematic review, we included trials in which any topical treatment (antihistamines, mast cell stabilizers, multiple action antiallergic drugs, vasoconstrictors, nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, cyclosporine, and other immunomodulatory compounds) and/or immunotherapy have been compared to no treatment, placebo or to another antiallergic drug. All types of study Dabrafenib cost design were considered for inclusion in this systematic review, including masked and unmasked studies, single- or multi-center, as well as randomized, quasirandomized, and nonrandomized studies. An evaluation of trials�� quality based on their design was conducted using the Jadad scale (20). This scoring system is based on a three-point questionnaire in which each question has to be scored with ��YES�� (1 point) or ��NO�� (0 points). The questions to be addressed are the following: 1 ?Was the study described as randomized? Based on the method of randomization and blinding used in the trials, additional two points may be given, resulting in a final score ranging from zero (poor quality) to five (excellent quality). It is generally accepted that studies with Jadad scores of 3 or greater reflect ��good�� reporting quality, whereas ratings of Ritonavir into two groups of two �C independently performed the literature search. The search resulted in a total of 677 titles. After matching the decisions of the two groups of observers, 79 papers were immediately excluded because they were not clinical trials. Of the remaining 598 http://www.selleckchem.com/products/sch772984.html titles, 255 were also excluded because not related to allergic conjunctivitis. Therefore, 343 full abstracts were retrieved. In addition, the most recent clinical trials registered on http://www.clinicaltrials.org in the last 5?years (up to April 2009) either recruiting patients, ongoing, or completed were searched with the same criteria, and additional 85 trials were found, for a total of 428 studies. Reviewers assessed in pairs the abstracts resulting from electronic searches. The article��s eligibility was initially determined by evaluating the titles, abstracts, and MeSH (medical subject headings). The full copy of all those that definitely or potentially met the inclusion criteria was obtained for further assessment of eligibility. Reviewers were not masked to trial results or publication details during the assessment. Articles were excluded if they were not clinical trials on allergic conjunctivitis, or if they were not retrieved after performing all available search strategies, including request to authors and editors.