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, 2004, 2007); the strongest hybridization signals were found in the endopiriform nucleus and in the motor cortex 2. The overall 2-way ANOVA with alcohol treatment and NPS ICV treatment as factors revealed a significant variation of the expression MASP1 of NPSR between nondependent and postdependent animals at both 12?hours and 7?days after intoxication ([F(1,8)?=?23.43; p??0.05] and in the height of the bedding pile [F(1,41)?=?2.4; p?>?0.05]. NPS treatment produced an overall significant effect in the burying time [F(2,41)?= 5.46; p?AZD6738 PFI-2 clinical trial significant effects of NPS treatment in postdependent rats: burying time, F(2,22)?=?6.58; p??0.05], time latency to burying [F(2,19)?=?2.03; p?>?0.05], and height of the bedding pile [F(2,19)?=?0.32; p?>?0.05]. The different efficacy of NPS in reducing anxiety-like behaviors in postdependent versus nondependent rats was confirmed by dose�Cresponse curve slope analysis that revealed a statistical difference for the burying time (p?