Your Mystery Weapon Available for FK228

Men and women were analysed separately. The same variables as above (except gender) were used with the addition of interventional hospital, year of inclusion, reperfusion therapy and Killip class regarding in-hospital mortality and also discharge therapy regarding long-term mortality. Kaplan-Meier survival curves were plotted for men and women in four CKD categories, according to MDRD and CG, respectively. Wilcoxon (Gehan) Statistics were used for comparisons between the CKD groups. Finally, a possible interaction between gender and eGFR regarding mortality was evaluated incorporating an interaction term (ie, the product of gender and eGFR) into logistic and Cox regression models, respectively, together with gender and eGFR and all other covariates. All statistical analyses were performed with SPSS V.18.0 (PASW selleck chemicals Statistics V.18) software (SPSS Inc, Chicago, Illinois, USA). Results Basic characteristics A total of 37?991 patients were included in the analyses, 25?062 (66%) men and 12?929 (34%) women. Women were older, had lower weight, body mass index (BMI), heart rate and Killip class on admission. They also had a higher prevalence of comorbidities such as diabetes, hypertension, COPD, PAD, previous stroke or dementia whereas men were more often smokers, had more often suffered from a previous MI and had more often been previously revascularised (table 1). Complete data were available for 35?352 (93%) patients regarding MDRD and 26?586 (70%) patients regarding CG. Patients with CKD, men and women, were older, had lower weight, BMI and systolic blood pressure but higher heart rate on admission, compared with patients with without CKD. The prevalence of cardiovascular risk factors and diseases, such as diabetes, hypertension, previous stroke, PAD, chronic heart failure or previous MI were higher in the patients with CKD but they were half as often smokers compared with the patients without CKD. Almost half of the CKD men and women were already on treatment with aspirin or ��-blockers on admission. They had higher plasma glucose on admission and lower haemoglobin and cholesterol levels. They much more often had signs of heart failure including cardiogenic shock or pulmonary oedema and all complications during hospital care were more common among patients with CKD of both genders. Around 70% of the women and 50% of the men with CKD had left ventricular dysfunction (ejection fraction