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""5682" "The efficacy of budesonide/formoterol maintenance and reliever therapy (BFMRT) in asthma control is well documented in large randomized controlled trials. However, the acute reliever effects and real-life effectiveness are seldom reported. This Anticancer Compound Library research buy multicenter trial enrolled steroid-na?ve, symptomatic asthmatics with baseline exhaled nitric oxide (eNO) of ��40?ppb. There were 120 eligible patients who were randomized and received a dose of inhaled budesonide/formoterol 320/9?��g (lower dose budesonide/formoterol), 640/18?��g (higher dose budesonide/formoterol (HDBF)), or terbutaline (TERB) 1?mg. Inflammatory cells and mediators in induced sputum, eNO and lung function were measured at baseline and 6?h (acute phase). Subsequently, all patients used BFMRT as real-life practice for 24 weeks (maintenance phase). In the acute phase, the degree of post-treatment reduction in total eosinophil counts, interleukin-8 and matrix metalloproteinase-9 in induced sputum were significantly greater in group HDBF (vs TERB, P?Sitaxentan Budesonide/formoterol as reliever exerts acute, this website dose-related anti-inflammatory effects and FEV1 improvement in symptomatic asthmatics. BFMRT is effective in asthma control. However, the decrease in long-term follow-up rate remains an issue to overcome in real-life settings. ""5683" "Mesothelioma is an incurable cancer with a rising global incidence. Intrapleural delivery of a commercially available compound made up of proteins produced by Staphylococcus aureus has been used clinically to induce pleurodesis. We investigate if this bacterial compound has anti-tumoural activities against pleural malignancies, in addition to its pleurodesing effect. The effects of the treatment on mesothelioma cells were evaluated in vitro and further tested in two validated murine models. This S.?aureus bio-product mixture effectively kills mesothelioma cells and induces the release of interleukin (IL)-8, monocyte chemotactic protein (MCP)-1 and vascular endothelial growth factor from primary human mesothelial cells but not malignant pleural mesothelioma cells in vitro. Intratumoural delivery of the treatment in BALB/c mice induced tumour necrosis and local activation of T cells. Tumour growth was significantly inhibited in the treatment group during and after the treatment period (size of tumour 58.8?��?10.3?mm2 vs 118.