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2). With the tibia held in neutral rotation, ACL forces during knee extension were not significantly different than those during knee flexion. With free tibial rotation, ACL forces during knee extension were significantly greater than corresponding Birinapant in vivo forces during knee flexion between 5�� and 50��. Anterior tibial displacements produced by applied axial tibial force were significantly greater for ACL deficient knees than corresponding values for intact knees at all flexion angles greater than 0��; this was true during knee flexion and knee extension (Fig. 3). Tibial displacements were significantly greater during knee extension than during knee flexion from 0�� to 35�� (intact knees), and at all flexion angles for ACL deficient knees (Fig. 3). Valgus tibial rotations produced by applied axial tibial force were significantly greater for ACL deficient knees than corresponding values for intact knees Gemcitabine order between 0�� and 50�� during knee flexion and between 5�� and 50�� during knee extension (Fig. 4). For intact knees, valgus rotations during knee extension were not significantly different than corresponding values during knee flexion (Fig. 4). For ACL deficient knees, valgus rotations during knee extension were significantly greater than corresponding values during knee flexion at flexion angles greater than 0�� (Fig. 4). Internal tibial rotations produced by applied axial tibial force were significantly greater for ACL deficient knees than corresponding values for intact knees at flexion angles between 5�� and 40�� during knee flexion Megestrol Acetate and between 0�� and 15�� during knee extension (Fig. 5). Internal rotations during knee extension were significantly greater than corresponding values during knee flexion between 5�� and 25�� for intact knees and between 0�� and 45�� for ACL deficient knees (Fig. 5). Application of 500?N axial tibial force generated an internal tibial torque that produced the ACL forces shown in Figure 2, and the tibial motions shown in Figures 3-5. With the ACL removed, the external tibial torque required to return the tibia to neutral rotation (which was equal and opposite to the internal torque acting to produce the rotation) varied with flexion angle (Fig. 6), ranging from 1.7?N-m?��?1.0 N-m (at 10�� flexion) to 4.3?N-m?��?2.9?N-m (at 45�� flexion). All generated torques were significantly different from each other (p?