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In addition, other studies have included pre-threshold criteria based on the Early Treatment for Retinopathy of Prematurity (ETROP) study,16 which treated some patients sooner than the defined threshold for CRYO-ROP with good results. This effectively changed the threshold for treatment. The most important change is that treatment can now be considered sooner without regard to the number of clock hours involved. The new criteria defined by ETROP and the clinical algorithm shows that in most circumstances,17 peripheral retinal ablation should be considered for any eye with type I ROP, zone I ROP with plus disease (regardless of stage), zone I ROP with stage 3 disease (with or without plus disease), zone II ROP, stage 2 or 3, with plus disease. selleck screening library Table 4 Data comparison between different studies Gilbert et al.18 compared gestational age and birth weight between countries with low, moderate, and high levels of development. In highly developed countries, they found that all infants with severe ROP had a mean gestational age Gemcitabine cell line Gestational age and birth weight were significantly correlated with ROP in the present study. Birth weight and gestational age in the ROP group were significantly lower than in the non-ROP group. These findings are consistent with other studies that birth weight and gestational age are important factors associated with ROP. In some recent studies, extremely premature infants with lower gestational age had a higher incidence of type 1 ROP. No infant with a gestational age >26 weeks at birth or birth weight >1000 g had type 1 ROP.19 Birth weight may not influence the incidence of type 1 ROP in extremely premature infants.20?ahin et al. was found no association between type 1 ROP and BW in extremely preterm infants with a GA of Megestrol Acetate of effective screening. Gilbert et al.22 suggest that the population of infants who develop severe ROP in highly developed countries differs from those who are affected in less well-developed countries, given the complex interaction between case mix, neonatal care, and survival rates, as well as variation in screening practices and follow-up rates of discharged infants, and retreatment programs. There are some limitations to this study. First, the study was conducted among in patients in the NICU and thus could misrepresent the general incidence of ROP.