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Although this is seen as the main mechanism of action, several others are seen to be offered by the unique properties of silicone-based products, a potential explanation for the lack of efficacy offered by alternative occlusive treatments. The clinical support of topical silicone gel products relative to all alternative scar therapies is what has preserved its position as the internationally recommended first-line form of scar management, favored by consensus among healthcare professionals. Although steroid injections offer significant positive impact on scarring, they remain a supporting treatment, in part, due to the associated expense and impracticality. Other existing treatments such as topical creams/gels and dressings containing active additives such as onion extract, vitamins C and E, and moisturizing agents are often seen to deliver little to no extra benefit than SGS itself. Take-Home Messages ??Topical silicone gel treatments seem to remain the first-line therapy for clinical recommendation in scar management. ??The exact mechanisms by which SGS improves hypertrophic scar and keloid development and recovery are yet to be fully eluded and agreed upon. ??There still remains the need for good clinical evidence to demonstrate the benefit of silicone gel for use in the prevention of abnormal scarring. Abbreviations and Acronyms AFR ablative fractional resurfacing PSA pressure sensitive adhesive SEI scar elevation index SGS silicone gel sheeting SSA soft skin adhesive Acknowledgments and Funding Sources No funding sources were Alpelisib clinical trial obtained for this review article. Author Disclosure and Ghostwriting B.B. is employed by Scapa Group plc., by whom the content of this article was expressly written. No ghostwriters were used to write this article. About the Authors Benjamin Bleasdale has held multiple positions at Scapa Healthcare; starting in Business Development before shifting to his current position in a cross-departmental Product Management function, working closely with marketing, R&D, and commercial groups. Leading research projects into various areas of adhesive use in healthcare, he has developed a broad specialized knowledge of the therapeutic use of adhesives in skin-contact applications. Ben holds a degree in Business Management. Sean Kelly has 14 years of experience in medical device R&D, project management, manufacturing, quality and regulations. He was Global Development Manager at Scapa Healthcare, part of the Scapa Group Plc. Before Scapa, Sean was employed as a Medical Device Regulator at the Notified Body (BSi) working with leading wound care and other medical device manufacturers. Before BSi, Sean worked at Advanced Medical Solutions, Bristol Myers Squibb, and ConvaTec Ltd.