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Categorical variables were compared by ��2 test. Statistical significance was assumed when p?buy PLX4032 whereas the IL-6 (?174) C/C (1.3% patients vs 16.3% controls, p?CT99021 observed ( Table 2). Gender differences in frequency distributions of genotypes were detected for IL-6 polymorphisms in ID patients. A significantly higher frequency in females than in males was observed for IL-6 (nt565) G/A SNP (p?PDGFRB CI: from 0.1475 to 0.9932) ( Fig. 4). No differences between patients and controls were detected for the other cytokine polymorphisms examined. To perform haplotype analysis of the IL6 gene, the genotype result of ?174 was considered, for each individual, together with the genotype result of nt565 SNPs. All combinations of haplotypes that were present in patients and controls are shown in Fig. 5. From this analysis, we observed that the GG/CA combination was associated with a significantly increased risk of ID as compared with the controls (38.1% patients vs 20% controls, p?