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Pediatr Pulmonol. 2013; 48:295�C302. ? 2012 Wiley Periodicals, Inc. ""We evaluated safety and efficacy of recombinant human growth hormone (rhGH) for improving growth, lean body mass (LBM), pulmonary function, and exercise tolerance in children with cystic fibrosis (CF) and growth restriction. Multicenter, open-label, controlled clinical trial comparing outcomes in prepubertal Sitaxentan children CX-5461 in vitro distance) at 1 year. Changes in glucose tolerance for the two groups were similar over the 12-month study period, with three subjects developing IGT and one CFRD in each group. One Forskolin clinical trial rhGH-treated patient developed increased intracranial pressure. Treatment with rhGH in prepubertal children with CF was effective in promoting growth, weight, LBM, lung volume, and lung flows, and had an acceptable safety profile. Pediatr Pulmonol. 2012; 47:252�C263. ? 2011 Wiley Periodicals, Inc. ""Sputum induction is a semi-invasive technique used to detect and monitor airway inflammation. In this study, the cell profile, and Th1 and Th2 cytokine levels in induced sputum of asthmatic and healthy children (HC) are compared. Sputum induction was performed in healthy and asthmatic children by inhalation of hypertonic saline solution. Differential cell count in the specimen obtained was carried out using optic microscopy. IFN-��, IL-2, IL-10, IL-8, IL-6, IL-4, IL-5, IL-1��, TNF-��, and IL-12p70 levels were determined in sputum sample supernatants by flow cytometry. Sputum induction was performed in 31 HC and 77 asthmatic children (60 atopic and 17 non-atopic asthma, NAA). Twenty-four samples were obtained in HC and 64 in patients. Median eosinophil count in atopic asthma (AA; 2%) was higher than in NAA (P?=?0.02) or HC (P?=?0.01).