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The duration and exclusivity of breastfeeding were ascertained from the baseline interview, where the mothers were asked whether they ever tried to breastfeed the cohort Mianserin HCl child, how old the cohort child was when s/he last received breast milk and how old the cohort child was when s/he first received formula, other milks or solid food. Breastfeeding was defined as exclusive if the cohort child had not received formula, other milks or solid food. The mothers were not specifically asked whether the children received water in addition to breast milk. The duration of any and exclusive breastfeeding were categorised into never, SCR7 molecular weight as a continuous outcome. The main outcome in our analyses was having reached Entinostat ic50 a good level of overall achievement. Secondary outcomes were having reached a good level of achievement in the six areas of development, which constitutes the FSP assessment. These definitions are used by the government and Local Authorities in the United Kingdom to assess the progress made by schools and Local Authorities in the field of early learning (Schools Analysis and Research Division, Department of Education 2010). A total score of ��78 points across the 13 scales and a score of ��6 in each of the three ��personal, social and emotional development�� scales and the four ��communication, language and literacy�� scales is defined as ��having reached a good level of overall achievement��. A scale score of ��6 points in all scales belonging to an area of development was defined as ��having reached a good level of achievement�� in that area (Table?1). For the models with continuous outcomes, the total FSP score was calculated by adding up the scores of all the sub-scales (areas of development) and the sub-scale scores by adding up the item scores from each subscale. We adjusted our models for two sets of covariates.