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Survey questions addressed core aspects of the research participants�� experience, including their overall rating, motivation, trust, and informed consent. We describe participant characteristics, responses to individual questions, and correlations among responses. Respondents broadly represented the research population in sex, race, and ethnicity. Seventy-three percent awarded top ratings to their overall research experience and 94% reported no pressure to enroll. Top ratings correlated with feeling treated with respect, listened to, and having access to the research team (R2 = 0.80�C0.96). White participants selleckchem trusted researchers more (88%) than did nonwhite participants collectively (80%; p Oxygenase items for improvement of participant's experiences, research protections, and the conduct of clinical investigation. ""1234" "In a paper published recently in this journal [1], Pedersen & Skardhamar examine whether cannabis users are at increased risk of being charged with criminal offences. They find an association between frequency of cannabis use in one year and risk of criminal charges in subsequent years. The association is statistically significant with respect to drug-specific crime only, and not to other types of criminal offences. The authors conclude that (i) ��.?.?.?use of cannabis does not seem to represent a risk factor for a general criminal involvement�� and (ii) that ��.?.?.?the fact that a considerable proportion of adolescents and young adults may come into contact with the penal system because of their involvement with cannabis must [.?.?.] give rise to concern. [.?.?.] The present study must be regarded as a new argument for the necessity to debate cannabis laws and the international conventions which regulate this area��. These conclusions are highly click here questionable, however, due to weaknesses in their data set and analyses: the model specifications and statistical power are inadequate; the outcome variable (charge with drug-specific crime) does not reveal with what type of drug the offender is charged (cannabis or hard drugs); and the vital control variable (hard drug use) does not cover the relevant time-period. Regarding the first conclusion: the models employed suffer from endogeneity problems, as both drug use and crime can be influenced by the same unobserved factors. Not controlling for unobserved heterogeneity may lead to biases in estimated coefficients. Moreover, the data set does not have the statistical power to support the stated conclusion due to the small number of observations and the complex model employed by the authors. In the multivariate analyses presented in Table 4 (p.