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001). A positive correlation (p?Alpelisib mechanical properties (maximum load, tensile extension, and stiffness) are presented in Table 4. The maximum load for Dabigatran the 3??g rhPDGF-BB dose group was significantly increased (p?��?0.025) compared to the saline, PRP, and TCA groups at day 7 and significantly increased (p?��?0.027) compared to the saline and TCA groups at day 21. The maximum load (p?��?0.035) and stiffness (p?��?0.038) were significantly increased in the 10??g rhPDGF-BB group compared to the saline, PRP, and TCA groups at day 21. Material mechanical properties (ultimate stress, tensile strain, and modulus) are presented in Table 5. The ultimate stress was significantly increased in the 3??g rhPDGF-BB dose group compared to the saline, PRP, and TCA groups at day 7 (p?��?0.025) and compared to the PRP group at day 21 (p?��?0.025). The ultimate stress (p?��?0.025) and modulus (p?��?0.046) were significantly increased in the Bosutinib clinical trial 10??g rhPDGF-BB dose group compared to the saline, PRP, and TCA groups at day 21. In this study, we compared rhPDGF-BB with corticosteroids and PRP in a rat model of tendinopathy. This collagenase-induced model[23, 31-34] presents aspects that are similar to human tendinopathy such as hypercellularity, loss of matrix organization, and lack of inflammatory cell infiltration, however, its main drawback is that it causes a healing response which is often absent in tendinopathy patients.[35, 36] This healing response can mask the effects of the treatments applied if the time points for assessment are not carefully defined. Guided by our previous experience,[23] we chose relatively short follow-up that would allow us to assess the effect and, potentially, the mechanism of action of the treatments applied. Although there are concerns about their long-term safety and efficacy,[8-10] corticosteroid injections are often administered for chronic tendinopathies. Growth factors have also been used to promote tendon healing in the form of PRP; however variability in the preparation and composition of PRP makes it difficult to compare results across studies[13] and it is likely responsible for the variability in the clinical outcomes reported with this therapy.