Title Loaded From File
?1A, B and C). Moreover, while remaining significant, the differences between the women and men decreased continuously as more time elapsed after their entry into the study (Fig.?1A, B and C). Young women suffering from severe asthma at the time of entry into our study had a lower overall mean score (P?Verteporfin mouse men, the severity of asthma exerted no significant impact on the overall mean score. Regular physical exercise (i.e. running, ball sports, aerobics, etc. ��2?h each week) at the time of entry into the study exerted a significant positive effect on the overall mean HRQOL score for the female subjects at this same time-point, as well as on their scores for 6 of the individual domains and the subdomains reflecting cognitive factors (i.e. activity and avoidance) and the emotional factor disability (Table?2). However, after 5 years of follow-up, these differences were no longer observed whereas a new difference with respect to ��common colds�� had appeared. In contrast, in the case of the young men, physical activity had no impact Vandetanib ic50 on any aspect of HRQOL at any time (not shown). There was no correlation between the FEV1 value (as a percentage of the predicted value) and overall HRQOL throughout the study (data not shown). Neither atopy nor bronchial hyperresponsiveness appeared to exert any impact on HRQOL. The HRQOL's of subjects receiving primary care or care at the specialized asthma clinic were similar (data not shown). The HRQOL, lung function, bronchial responsiveness, working capacity and atopy of the dropouts were the same as for those who completed this study (data not Itraconazole shown). At the time of entry into the study, the major differences described above were not altered by adjusting for atopy, regular exercise, gender. treatment with inhaled steroids, smoking habits (active, passive) and severity of asthma employing to a logistic regression model(data not shown). However, this model did reveal that poor adherence to the recommended asthma treatment was associated with lower HRQOL (odds ratio?=?0,29; 95% confidence interval?=?0.11�C0.73; P?
