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Significance was accepted at P�� 0.05. To estimate the extent of the errors resulting from the limitations of fascicle architecture measurements, the standard error was calculated between estimates of specific tension calculated with the correct muscle architecture and architecture from an altered knee angle and from a contraction at 90% of MVC. All data are reported as selleck screening library means ��s.d., unless otherwise stated. The peak Fquad occurred at a dynamometer set knee angle of ?75 deg for men, women and girls, and ?70 deg for boys; the standard deviations were between 6 and 9 deg for all groups. This equated to goniometer measured knee angles of 61.2 �� 4.8, 68.1 �� 8.9, 57.7 �� 9.4 and 62.1 �� 9.4 deg for men, women, boys and girls, respectively. The ANOVAs examining JointMVC, antagonist moment, voluntary activation level, Quad100%, moment arm, Fpt and Fquad revealed that there were significant Resiquimod differences between the groups for all measurements (P= 0.014 for antagonist activation; for all others P selleck inhibitor head in all the groups. As with the size of each individual head, the volume, PCSA and PCSA �� cos?�� of the entire quadriceps was greater in men compared with women and in adults compared with children (P