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The population of BC has been rising fairly fast, so that age- and sex-standardized rates of these estimated deaths actually fell during this period, from 25 to 24 per 100?000 residents [5, 6]. Furthermore, the main results highlighted in our Addiction paper did not require the use of attributable fractions because they concern causes of death that are wholly alcohol-attributable, e.g. alcohol poisoning, alcoholic gastritis, alcoholic cardiomyopathy. Figure?1 below reports trends for the two main variables used in our analyses. One line shows age- and sex-standardized rates of death that, according to the BC Statistics Agency, were caused wholly by alcohol. The second line shows changes in the inflation-adjusted average minimum price for all alcohol sold in BC calculated as dollars per Canadian standard drink (=13.45?g of ethanol, somewhat larger than a UK ��unit�� of 8?g). It can 17-DMAG (Alvespimycin) HCl be seen that in the first 4 years rates of death were increasing, while average minimum prices were decreasing relative to inflation. In 2006 there was a marked increase in minimum price which was associated with a marked drop in the rate of wholly alcohol-caused deaths. A significant negative association was found between these two variables in our original analysis [4], from which we estimated that a 10% increase in the average minimum price of alcohol would be associated with a 32% decrease in wholly alcohol-caused deaths. We could equally well have said that a 10% decrease in minimum price would be associated with a 32% increase in wholly alcohol-related deaths. GSK2656157 mw The Pearson coefficient of correlation between the minimum price and wholly I-BET151 solubility dmso alcohol-caused deaths was ?0.504, (P?